PhD, Stony Brook University, 1988
Presidential Faculty Fellow (White House/NSF), 1992-1997;
International Dennis Gabor Award (Hungary), 1996; Kurt Heinrich
Award (Microbeam Analysis Society), 2001; R&D 100 award
Fellow, American Association for the Advancement of Science,
2002-present; American Physical Society, 2011-present; Optical
Society of America, 1999-present
|Associate Division Director,
Advanced Photon Source,
Argonne National Laboratory
9700 S. Cass Avenue
Argonne, IL 60439-4837, USA
Interim Group Leader, Detectors Group
|Professor, Department of
Physics & Astronomy
2145 Sheridan Road
Evanston, IL 60208-3112, USA
Office: Pancoe 4105
Faculty member, Graduate
Faculty member, Chemistry
Life Processes Institute
Chris Jacobsen's research
group is focused on developing new methods in x-ray
microscopy, and applying them to interesting problems in biology,
environmental science, and materials science. Using either
diffractive optics (like Fresnel zone plates fabricated using
electron beam lithography), or lensless methods where iterative
phase retrieval methods are used to reconstruct an image from a
coherent diffraction pattern, images with a spatial resolution of
30 nm or better can be obtained. In absorption contrast, one
can combine imaging with spectroscopy to study chemical speciation
at the nanoscale, or one can use fluorescence detection to study
trace element distributions with parts-per-billion
sensitivity. We are also developing detectors and image
reconstruction algorithms that can be used to obtain quantitative
phase contrast images with hard X rays, and thus put elemental
distributions into their ultrastructural context and also go from
measurements of content to measurements of concentration (since
concentration gradients drive chemical processes). Finally,
we are interested in understanding the limitations that radiation
damage presents to x-ray microscopy studies, and in developing
both cryo instrumentation and sample preparation methods to
mitigate those limitations. These efforts require bright
x-ray beams, so we use synchrotron radiation sources at Argonne
Lab, Berkeley Lab, and elsewhere. Students in the group
explore interesting problems in optical physics and in
instrumentation, and get to broaden their perspective by working
with collaborators from other research fields like biology,
environmental science, and materials science.
- Roger Falcone, Chris Jacobsen, Janos Kirz, Stefano Marchesini,
David Shapiro, and John Spence, "New directions in X-ray
293-318 (2011). [PDF]
- C. Holzner, M. Feser, S. Vogt, B. Hornberger, S.B. Baines, and
C. Jacobsen, “Zernike phase contrast scanning microscopy with
X-rays,” Nature Physics 6, 883-887 (2010) [PDF]
- M.D. de Jonge, C. Holzner, S.B. Baines, B.S. Twining, K.
Ignatyev, J. Diaz, D.L. Howard, D. Legnini, A. Miceli, I.
McNulty, C.J. Jacobsen, and S. Vogt, “Quantitative 3D elemental
microtomography of Cyclotella meneghiniana at 400-nm
resolution,” Proceedings of the National Academy of Sciences
107, 15676-15680 (2010). [PDF]
- J. Nelson, X. Huang, J. Steinbrener, D. Shapiro, J. Kirz, S.
Marchesini, A.M. Neiman, J.J. Turner, and C. Jacobsen, “High
resolution x-ray diffraction microscopy of specifically labeled
yeast cells,” Proceedings of
the National Academy of Sciences 107, 7235
- J. Steinbrener, J. Nelson, X. Huang, S. Marchesini, D.
Shapiro, J. J. Turner and C. Jacobsen, "Data preparation and
evaluation techniques for x-ray diffraction microscopy", Optics Express 18, 18598-18614, (2010).
- X. Huang, J. Nelson, J. Kirz, E. Lima, S. Marchesini, H.
Miao, A.M. Neiman, D. Shapiro, J. Steinbrener, A. Stewart, J.J.
Turner, and C. Jacobsen, “Soft x-ray diffraction microscopy of a
frozen hydrated yeast cell,” Physical
Review Letters 103,
198101 (2009). [PDF]
- M. Howells, T. Beetz, H. Chapman, C. Cui, J. Holton, C.
Jacobsen, J. Kirz, E. Lima, S. Marchesini, H. Miao, D. Sayre, D.
Shapiro, J. Spence, and D. Starodub, “An assessment of the
resolution limitation due to radiation-damage in x-ray
diffraction microscopy,” Journal
of Electron Spectroscopy and Related Phenomena 170, 4–12 (2009). [PDF]
- M. D. de Jonge, B. Hornberger, D. Paterson, C. Holzner, D.
Legnini, I. McNulty, C. Jacobsen, and S. Vogt, “Quantitative
phase imaging with a scanning transmission x-ray microscope,” Physical Review Letters 100, 163902 (2008). [PDF]
- J. Lehmann, D. Solomon, J. Kinyangi, L. Dathe, S. Wirick, and
C. Jacobsen, “Spatial complexity of soil organic matter forms at
nanometre scales,” Nature
238-242 (2008). [PDF]
- D. Shapiro, P. Thibault, T. Beetz, V. Elser, M. Howells, C.
Jacobsen, J. Kirz, E. Lima, H. Miao, A. M. Neiman, and D. Sayre,
“Biological imaging by soft x-ray diffraction microscopy,” Proceedings of the National
Academy of Sciences 102,
15343-15346 (2005). [PDF]
- C.K. Boyce, M.A. Zwieniecki, G.D. Cody, C. Jacobsen, S.
Wirick, A.H. Knoll, and N. M. Holbrook, “Evolution of xylem
lignification and hydrogel transport regulation.” Proceedings of the National
Academy of Sciences 101,
17555-17558 (2004). [PDF]
- J. Kirz, C. Jacobsen, and M. Howells, “Soft x-ray microscopes
and their biological applications.” Quarterly Reviews of Biophysics 28, 33-130 (1995). [PDF]
I maintain a public calendar using
Zimbra at the Advanced Photon Source at Argonne National Lab. You
can view the calendar here.